An evaluation of protracted low dose rate irradiation from an acute dose survival curve

Effect of refuelling on dose rate in an irradiation facility.

Differential Responses of Stress Genes to Low Dose-Rate ; Irradiation

In the past, most mechanistic studies of ionizing radiation response have employed very large doses, then extrapolated the results down to doses relevant to human exposure. It is becoming increasingly apparent, however, that this does not give an accurate or complete picture of the effects of most environmental exposures, which tend to be of low dose and protracted over time. We have initiated ...

Continuous Low-Dose-Rate Irradiation Promotes Growth of Silkworms

To investigate the influence of low-dose-rate irradiation on the growth of silkworms, Bombyx mori, eggs of silkworms were randomly divided into 2 groups and were grown on either low-dose-radiation-emitting sheets or control sheets. On the radiation-emitting sheets, the dose rate was measured as 66.0 (4.3) μSv/h (mean [standard deviation]) by a Geiger-Müller counter for α, β, and γ rays and 3.8 ...

Scientific Risk Estimation on Health Effects of Low Dose and Low Dose-Rate Radiation - An Overview

Estimation of the scientific risks of high dose radiation has been successfully quantified by many studies using several different approaches. However, the risk for low and low dose-rate radiation is obscure because of a lack of evidence. This risk is currently estimated by extrapolating the radiation response at high doses into low dose ranges for practical purposes. Recent challenges to exami...

Effects of gemcitabine on cell survival and chromosome aberrations after pulsed low dose-rate irradiation.

The radiosensitizing potential of gemcitabine (2',2'-difluoro-2'-deoxycytidine) was studied in combination with pulsed low dose-rate irradiation. The experiments were carried out with a human lung carcinoma cell line SW1573. These were irradiated at pulsed low dose rate (p-LDR); the average dose rate was 1 Gy/h. In the experiments with gemcitabine, this drug was applied for 24 h at a concentrat...